Drug Discovery and Development Poster Abstracts

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Human Mast Cells Express TLR 3, 7 and 9, TLR-9 mRNA is Induced by Viral DNA Sequence K3 CpG-ODN Hyde, Papadapoulou, Theoharides
Flavonols Inhibit Proinflammatory Mediator Release, Intracellular Calcium Ion Levels and Protein Kinase C Theta Phosphorylation in Human Mast Cells Kempuraj, Boucher, Theoharides
Mast Cells Activate T Cells in Multiple Sclerosis: Inhibition by Luteolin Kempuraj, Tagen, Eliopoulou, Vasiadi, Boucher, House, Theoharides
Mixed Lineage Kinase 7 is the Mitogen Activated Protein Kinase Kinase Kinase that Mediates Transduction of the Shiga Toxin Induced Ribotoxic Stress Signal Jandhyala, Ahluwalia, Obrig, Bloem, Thorpe
Effector Binding by Bacillus Subtilis CodY, a Global Regulator of Stationary Phase and Virulence Genes Handke, Shivers, Sonenshein
Therapeutic Reversal of IgA Nephropathy (IgAN) Plaut, Qiu, Bonis, Pilichowska
Comparison of Oscillometric vs. Auscultatory Methods of Blood Pressure Measurement in Subjects with Chronic Kidney Disease Walker, Perrone, Miskulin
Mechanism by Which Avenanthramide-C, a Polyphenol of Oats, Blocks Cell Cycle Progression in
Vascular Smooth Muscle Cells
Nie, Wise, Meydani
Methyl Ester of Avenanthramide-C Inhibits Cytokine-Induced NF-κβ Activation in Endothelial Cells Guo, Wise, Meydani
CCN5 Suppresses Restenosis in a Mouse Vascular Injury Model Malmquist, Aronovitz, Mendelsohn, Karas, Castellot
Estrogen Inhibits Cardiomyocyte Hypertrophy in vivo and in vitro via Inhibition of Calcineurin-NFAT Signaling Patimalla, Eder, Aronovitz, Pourati, Mendelsohn, Force, Molkentin, Karas, Patten
Simvastatin Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in ApoE Knockout Mice Zhang, Park, Schultz, Beasley, Moulton, Galper
Relationship Between Ventricular Premature Contractions (VPC) and Fatty Acid Concentrations in Boxers Versus Doberman Pinschers Freeman, Smith, Meurs, Rush, Lamb, Bibus
Fish Oil Reduces Ventricular Arrhythmias in Boxer Dogs with Arrhythmogenic Right Ventricular Cardiomyopathy Smith, Freeman, Cunningham, Rush
Nutritional Effects of Dietary Modification in Early Canine Chronic Valvular Disease Freeman, Rush, Markwell
Cardiovascular Effects of Dietary Modification in Early Canine Chronic Valvular Disease Freeman, Rush, Markwell
Relationship Between Cachexia and Lymphocyte Subpopulations and Hematologic Parameters in Dogs with Spontaneously-Occurring Congestive Heart Failure Freeman and Rush
ABCG5/8 and NPC1L1 Polymorphisms and Response to Pravastatin in PROSPER Polisecki, Gaw, Shepherd, Ford, McMahon, Schaefer
Interindividual Variability in Ethanol Glucuronidation by Human Liver Hesse, Von Moltke, Greenblatt, Court
Identification of a Non-Peptide Inverse Agonist for a Class B G Protein-Coupled Receptor Doran, Masur, Tibaduiza, Leitz, Kopin, Beinborn
Dopaminergic Deficits in Murine Models of Obesity and Leanness Frank, Stiles, Geiger, Pothos
Repeated Ropinirole Treatment Reverses Sensorimotor Gating Deficits in Rats Krupin and Hammer, Jr.
Axonal Regeneration and Recovery of Synaptic Function in Rats Following Dorsal Root Crush and sNgR Treatment Cariani, Walsh, Frank
Key Molecules for Neuronal Nicotinic Synapse Assembly and Function Rosenberg, Yang, Mohn, Storer, Giovanni, Jacob
Identification of Human CD8+ and CD4+ Lymphocytes with Unique Drug Resistance Activity by Imaging the Drug Transport Kinetics at the Single Cell Resolution Bertelsen, Haigh, Biran, Deutsch, Zurgil, Greenblatt, Von Moltke, Shirihai
Biofilm Formation by Fluconazole-Resistant C. Albicans Strains is Inhibited by Fluconazole Bruzual, Riggle, Hadley, Kumamoto
Proteomic and Mass Spectrometry Research at Tufts Proteomics Core Facility DeGnore, Nguyen, Berne
The Structural and Chemical Biology Program of the T–NEMC Cancer Center Baleja
T–NEMC Expression Array Core: An Open, Integrated, Collaborative Resource Flynn and Shao
Resistance Training and Timed Amino Acid Supplementation Protects Against the Loss of Muscle Mass and Strength with Disuse Castaneda-Sceppa, Cloutier, Cadena, Pearlman, Brooks, Layne, Roubenoff
The Influence of Lutein and Docosahexaenoic Acid on their Serum Concentrations, Macular Pigmentation and Lipoproteins Johnson, Caldarella, Chung, Snodderly
The Influence of Docosahexaenoic Acid and Lutein on Cognitive Function in Older Women Johnson, McDonald, Caldarella, Chung, Snodderly
Practical Segmentation of the eClinical Technology Market Cabanilla and Young
Trends in Postmarketing Commitments (PMCs) for FDA-Approved Drugs Faden
Oral Tissue, Salivary and Teeth Associated Microbiota in Sjogrens, Healthy and Periodontitis Patients Singh, Socransky, Haffajee, Papas
Progression of Periodontitis in a Medication Induced Saliva Hypofunction Population Singh, Martuscelli, Singh, Papas, Biesbrock
Curcumin, a Dietary Supplement Found in Curry Spice, Inhibits Metabolism of Acetaminophen (Tylenol®) in Ls180 Colon Cells Volak, Bekaii-Saab, Greenblatt, Court
Relation of Genetic Polymorphisms in the 3’ Untranslated Region of the Pregnane X-Receptor Gene to Cytochrome P450 3A4 Metabolism Oleson, Court, He, Von Moltke, Greenblatt
Influence of Age, Gender, Testosterone, Oral Contraceptives, and Ketoconazole on CYP3A Activity Gan, Harmatz, Stewart, Court, Greenblatt
Pharmacokinetic and Pharmacodynamic Interactions Between Zolpidem and Caffeine Farkas, Cysneiros, Harmatz,
Von Moltke, Greenblatt
Structures of Clostridium Botulinum Neurotoxin Serotype A Complexed with Small Molecule Inhibitors Highlight Active-Site Flexibility Silvaggi, Boldt, Wilson, Hixon, Stein, Tzipori, Janda, Allen
Identifying Exosite Inhibitors of Botulinum Proteases Using Non-Truncated Substrates Wilson, Stein, Glicksman, Tzipori
Development of Small Molecule Inhibitors of Botulinum Neurotoxin Protease Using Combinatorial Library Design Boldt, Kennedy, Hixon, Accurso, McAllister, Barbieri, Tzipori, Dickerson, Janda
Designer E3 Ligases to Accelerate BoNT LC Turnover in Neurons Oyler, Kincaid, Tzipori, Shoemaker
The Botulism Therapeutics Development Program at Tufts MBRU Shoemaker, Park, Mukherjee, Tzipori
Innovations in Wound Healing and Tissue Regeneration Research Ira Herman Laboratory
Design and Synthesis of Small Molecule Inhibitors of Endothelial Lipase, an HDL Regulating Drug Target O'Connell and Bachovchin
Novel 3D Tissue Models of Human Cancer: Identification of Therapeutic Targets in Translational Drug Discovery and Development Garlick, Alt-Holland, Shamis, DesRochers, Arnaud, Riley, Egles, Herman
Direct Protein Knockdown Screen in Cancer Cells for Drug Target Identification and Functional Validation Hauptschein, Sloan, Torella, Moezzifard, Giel-Moloney, Zehetmeier, Unger, Ilag, Jay
Metabolic Flux-Based Reaction Modules in Liver Drug Transformation Yoon and Lee
Modeling Complex Reactions and Crystallization Processes in the Manufacturing of Pharmaceuticals Georgakis, Wong, Schupmann, Makrydaki
A Nano-Scale Polymeric Drug Delivery Vehicle Panilaitis, Mercaldi, Curtis, Castro, Bora, Kaplan
Controlled Drug Release from Silk-Based Biomaterials Wang, Wang, Zhang, Kaplan
Biodistribution of a Radiolabeled Morpholino Oligomer and a Morpholino-Antibody in Normal Dogs Azuma, Liu, Johnson, Hunt, Dou, Solano, Payne, Rusckowski, Hnatowich
Correlation of Tumor Growth Kinetics, Cell Kill, and Radiotherapeutic Response in a RIF-1 Tumor Model Using Multispectral Analysis Henning, Azuma, Sotak, Helmer
Preparations for Mapping Genes Associated with Canine Hemangiosarcoma Kalbko, Shaw, Poulson, Barber, Keating, Linblad-Toh, Azuma
Human Breast Cancer Metastasis to Tissue Engineered Bone Scaffolds in a Mouse Model Moreau, Anderson, Mauney, Kaplan, Rosenblatt
Fiber Optic Single Cell Drug Screening Whitaker and Walt
The Optical LiveCell™ Array, a Novel Single Cell Based Microarray Technology: Applications for Drug Discovery and Diagnostics Biran, Haigh, Drori, Zurgil, Deutsch, Shirihai
The Jak/STAT Pathway as a Therapeutic Target for Glioblastoma Konnikova, Reeves, Kotecki, Cochran
The HBPL Transcriptional Repressor Regulates Premature Senescence and Tumorigenesis Yee, Kim, Roth, Zhang, Ma, Paulson, Wazer, Kuperwasser
Designing a Repressor of Human Papillomavirus E2 Protein With Potential for Antiviral Therapy Bose, Yoder, Mancebo, Baleja
Inhibition of Lung Carcinogenesis by 9-cis Retinoic Acid and 1α,25-Dihydroxyvitamin D3 in the A/J
Mouse Model: Evidence of Retinoid Antagonism of Vitamin D
Mernitz, Smith, Wood, Russell, Wang
Apo-10’-Lycopenoic Acid Suppresses Lung Cancer Cell Growth by Activating Retinoic Acid Receptor β in vitro, and Inhibits Lung Tumorigenesis in vivo in the A/J Mouse Model Lian, Smith, Ernst, Russell, Wang
Safer Cancer Drugs Through the Development of Pro-Soft Proteasome Inhibitors Lai, Bachovchin, Milo, Jr.
Inhibition of Choroidal Neovascularization by Adenovirus-Mediated Delivery of Short Hairpin RNAs Targeting VEGF as a Potential Therapy for Age Related Macular Degeneration Cashman, Bowman, Christofferson, Kumar-Singh
The Effects of Grape Juice on Cognitive and Motor Deficits in Aging Shukitt-Hale, Carey, Simon, Cheng, Mark, Joseph
Characterization of Constitutively Active GABA-B Receptors as Potential Tools for Drug Discovery Mukherjee, McBride, Beinborn, Dunlap, Kopin
Plasma Phosphatidylcholine Dochosahexaenoic Acid Content and Risk of Dementia and Alzheimer Disease Schaefer, Bongard, Beiser, Lamon-Fava, Robins, Au, Tucker, Kyle, Wilson, Wol
Identification of Ubiquitin-Conjugating Enzyme Ubc4-Specific Substrates in Rat Lens Zhou, Shang, DeGnore, Taylor




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